Industrial Technology Research Institute

Technology Overview

ITRI has developed an eye drop product utilizing its proprietary Coordination Supramolecular Complex (CSC) technology combined with an active pharmaceutical ingredient to treat dry age-related macular degeneration (dry AMD) and help prevent vision loss. This unique formulation enhances drug exposure in targeted ocular tissues. Furthermore, it preserves the function of photoreceptors and retinal pigment epithelium (RPE) by reducing endoplasmic reticulum (ER) stress and sub-RPE deposits, thereby providing neuroprotective benefits. This technology also holds potential for developing treatments for other posterior segment ocular diseases.

Features & Specifications

• The proprietary eye drop formulation, made with FDA-approved excipients, effectively delivers drugs to the posterior segment of the eye.
• The repurposed drug, delivered via eye drops, demonstrated superior efficacy in preserving photoreceptor integrity and reducing sub-RPE deposits compared to the intravitreal injection of the benchmark drug, Risuteganib.
• Ocular safety and tolerability were demonstrated in rabbits following three months of continuous eye drop administration.

Applications & Benefits

• Non-invasive therapy for intermediate to late-stage dry AMD, improving convenience and patient compliance.
• Unlocking new market opportunities in posterior segment care with proprietary ocular delivery technology.

One-Stop Biomedical Services

• Listing Regulations Consulting: FDA/TFDA/CE application, medical device verification/export, medical device/medicine registration, IRB document organization, clinical trial application, and more.
• Technology Transfer: Bio-IT, diagnostics and precision medicine technology, regeneration medicine technology, natural medicine and healthcare technology, targeted drug and delivery technology.
• Model Translation: Domestic supply chain linkage, medical device design control, market analysis, strategy analysis of regulation in commercialization, and more.
• Preclinical/Clinical Trial: Functional safety assessments, clinical research organization linkage, clinical evaluation and analysis, clinical trial planning, clinical trial analysis and reports.
• Other Services: Quality system consulting, commercialization consulting, smart health solutions, software validation, medical device risk management, information security risk evaluation, technical documents preparation, business ecosystem linkage, and more.