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工業技術研究院

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EGFR變異富集檢測試劑開發

技術簡介

 EGFR顯示照
EGFR顯示照

EGFR變異富集檢測試劑為一套分子定性試劑,能有效偵測EGFR基因Exon 19-21之體細胞突變。以專一核酸引子搭配3端修飾核酸引子阻斷子(Blocker),此試劑組可分辨6型EGFR基因變異,且具有高靈敏度與專一性之特性,可應用於在組織切片(FFPE) 檢測。

特色與創新

  • 高專一性與靈敏度(<1%)
  • 僅需少量檢體(16-40 ng)
  • 5小時內即可完成檢測(含檢體處理時間)

應用與效益

可發展為輔助性診斷(Complementary Diagnostics) ,用於檢測非小細胞肺癌病患是否帶有EGFR變異,以期對病患進行有效分群,以進行精準醫療(precision medicine)。

本計畫所開發之變異富集檢測技術,可廣泛應用到需要伴同診斷之標靶用藥與相關疾病,例如: 大腸直腸癌(colorectal cancer)、乳癌(breast cancer)等,可提供醫師進行更正確與快速之治療指引。

技術優勢。
技術優勢。

EGFR變異富集檢測試劑開發。
EGFR變異富集檢測試劑開發。

試劑效能。
試劑效能。



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