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Industrial Technology Research Institute

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Antibody-Drug Conjugates (ADCs)

Technology Overview

Antibody-Drug Conjugates (ADCs).
Antibody-Drug Conjugates (ADCs).

Although using medicine to treat cancer can kill cancer cells, this may have side effect to the drugs and harm healthy tissues and organs. ITRI has developed a new generation drug delivery technology, Antibodydrug Conjugate (ADC), which can not only differentiate cancer cells from normal cells but also precisely deliver drugs to the cancer cells to kill them without harming healthy ones.

The ADC is composed of three parts, a monoclonal antibody (mAb), linkers, and small molecule drugs. Among them, the linker is a crucial factor determining ADC manufacture complexity and treatment efficacy.

Applications & Benefits

ITRI’s proprietary patented glycopeptide linker can increase the plasma stability of the ADC and avoid harm to normal cells. ITRI has also produced a proprietary patented highly specific linker that enables the conjugation of a specific number of drugs to antibodies when producing the ADC. This significantly reduces the complexity of ADC manufacture and accelerates the development of ADC products.

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