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工業技術研究院

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技術名稱: Nimodipine合成技術

技術簡介

Nimodipine為1,4-dihydropyridine系鈣管阻斷劑,其合成步驟包括Acetoacetic ester合成,β-Aminocrotonate合成、縮合及Hantzsch pyridine合成(環化)。關鍵步驟縮合及環化兩步總效率達70%以上,產品純度大於99%。

Abstract

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技術規格

Technical Specification

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技術特色

所建立之高產率及高純度Hantzsch Pyridine合成技術,可應用於1,4-DHP鈣管阻斷劑系列產品。

應用範圍

醫藥品(用於治療高血壓、心絞痛)。

接受技術者具備基礎建議(設備)

高效能HPLC、GC、一般反應器。

接受技術者具備基礎建議(專業)

化學、化工。

技術分類 藥物治療

聯絡資訊

聯絡人:黃崇雄 化學藥物工程研究室

電話:+886-3-5732543 或 Email:KenHwang@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732374

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