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工業技術研究院

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技術名稱: 抗憂鬱藥Sertraline合成

技術簡介

抗憂鬱用藥Sertraline製備之關鍵技術包括Friedel-Crafts反應,化學光學分割及還原胺化等,本製程還原胺化更突破專利技術,建立無污染性、無爆炸性、易操作製程,更顯著的是立體選擇比值大於9遠高於專利的比值2。

Abstract

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技術規格

Technical Specification

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技術特色

1.製備簡化,設備投資額低 2.無重金屬、無醚類溶劑之新穎製程 3.還原胺化之轉化率> 75%

應用範圍

1.原料藥與精密化學品之製備 2.具光學活性之藥物及精密化學品製備

接受技術者具備基礎建議(設備)

玻璃襯裡反應槽、結晶槽、過濾器

接受技術者具備基礎建議(專業)

化學、化工。

技術分類 藥物治療

聯絡資訊

聯絡人:黃崇雄 化學藥物工程研究室

電話:+886-3-5732543 或 Email:KenHwang@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732374

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