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工業技術研究院

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技術名稱: Iopamidol中間體公斤級製程放大

技術簡介

非離子性水溶性新生代造影劑-Iopamidol,可用於神經造影,血管造影,腦室X光造影,電腦中斷層掃瞄增強造影,尿路造影等。全世界診斷劑的銷售額為40億美元以上,其中Iopamidol與其它同類藥物Iohexol等產品之銷售額超過10億美元,Iopamidol為義大利Bracco公司的專利藥品, 其專利已於1998年到期。Iopamidol的製程技術若能量產,一方面可取代進口,一方面可將技術應用到其他診斷劑。Iopamidol經由碘化、氯醯化、醯胺化、胺化,C3光學活性中間體製備及水解等反應而得,反應過程相當繁複且分離純化難度甚高。工研院目前所開發的Iopamidol製程技術具有高反應收率,平均每步驟反應收率>80%,產品以離子交換樹脂化技術克服產品不易分離純化之問題,產品純度可達98%。

Abstract

none

技術規格

反應溫度範圍-10oC~120oC 操作壓力範圍 0~5 Kg/cm2

Technical Specification

none

技術特色

高反應效率、高收率、高純度

應用範圍

結構為非離子性苯碘化合物之造影劑原料藥。

接受技術者具備基礎建議(設備)

需備有玻璃內襯反應器、精密過濾器、乾燥器、蒸餾塔、蒸氣鍋爐等

接受技術者具備基礎建議(專業)

需具備藥學、化學、化工大學以上之專業人員

技術分類 藥物治療

聯絡資訊

聯絡人:黃崇雄 化學藥物工程研究室

電話:+886-3-5732543 或 Email:KenHwang@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732374

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