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工業技術研究院

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技術名稱: 前驅藥物開發技術

技術簡介

前驅藥物開發技術主要是以藥效、藥動學理念,設計合成與篩選低生體可用率藥物之研發為主軸。本中心之技術包含前驅藥物之結構設計研究、製備方法、In vitro試驗與In vivo藥效、藥動學之藥物血中濃度探討,協助廠商進行前臨床試驗之規劃,藥物之市場前景分析。

Abstract

The prodrug can improve drug’s oral bioavailability and produce blood levels greater than those attained by the parent drug. Prodrug Development Technologies include design, synthesis the prodrug of marketing drug molecules or drug candidates followed by using in vitro cell-based and in vivo animal assays to screen out the best prodrug with optimized pharmacokinetics profile.

技術規格

1)選用Rule -of -5,Drug-Like的藥物吸收性質之篩選規範,進行藥物初篩。2) 前驅藥物在動物試驗中,釋出藥物之藥動參數AUC及Cmax較原藥為優,延長藥物在血中之有效濃度的時間(依不同之藥物而定),減少副作用,增加服用的方便性。

Technical Specification

BMEC is improving the bioavailability of small synthetic drug molecules by engineering their molecular structure follow the Rule- of-5 and drug -like characters to take advantage of absorption mechanisms. Conducting preclinical pharmacokinetic studies to

技術特色

包含藥物設計、分析方法建立、實驗室製程及in vitro篩選評估、In vivo動物活性試驗之規劃等事項,提供完整前驅藥物技術開發技術平台。

應用範圍

各種需轉換成長效型、釋控劑型之藥物、健康食品之有效成分均可利用此技術,進行產品加值。

接受技術者具備基礎建議(設備)

需具有機合成、生科、儀器分析之相關設備。

接受技術者具備基礎建議(專業)

藥學、化學、生科等相關領域。

技術分類 藥物治療

聯絡資訊

聯絡人:黃振倉 藥物化學工程研究室

電話:+886-3-5732897 或 Email:jth@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732374

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