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工業技術研究院

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技術名稱: 細胞級kinase抑制劑篩選技術

技術簡介

細胞級kinase篩選系統,除了可驗證腫瘤藥物作用的標靶以外,也可用來篩選潛力抗癌標靶藥物,目前此一篩選系統包括Flt-3、c-KIT、PDGFR、KDR、EGFR等kinase之分析篩選技術。以蛋白質酪胺酸kinase為標的進行藥物研發已是國際藥廠抗腫瘤藥物研究的重點,並且已有十多種蛋白質酪胺酸kinase抑制劑和抗體進人臨床試驗並獲得核准上市。

Abstract

The established methods supply the evidence to demonstrate that this inhibition of cellular phosphorylation is indeed mechanism-based and not due to general cytotoxicity. This evaluating platform can accelerate drug discovery/lead optimization and novel potential kinase inhibitor can also be discovered for cancer therapy.

技術規格

1.以既有藥物當控制組。 2.分析物之抑制率(%)。 3.分析物之抑制濃度測定(IC50)。

Technical Specification

1.Existing drug as positive control. 2.Inhibition rate of determined agent. 3.Half maximal inhibitory concentration of determined agent.

技術特色

已完整建立此一分析平台,可提供分析服務;並可擴充至其他kinase分析。

應用範圍

抗癌藥物篩選,藥效標靶鑑定。

接受技術者具備基礎建議(設備)

細胞培養室及設備、蛋白質電泳設備、酵素免疫分析儀、影像分析儀、沖片暗房等。

接受技術者具備基礎建議(專業)

細胞培養、蛋白質分析鑑定、生化學分析技術

技術分類 藥物治療

聯絡資訊

聯絡人:陳燕春 小分子藥物技術組

電話:+886-3-5732561 或 Email:YenChunChen@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732359

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