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工業技術研究院

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技術名稱: 治療C肝中草藥新藥開發

技術簡介

由單一植物萃取成分,以利用特殊C肝病毒部份基因體結構在人類肝癌細胞可複製細胞系統分析出其抑制C肝病毒複製之活性,以初級肝細胞與動物進行藥物毒性評估,經純化分子鑑定初期純化合物之結構並已再確認其具有抑制C肝病毒複製之生物活性,完成初步之藥理評估認為具有開發成為治療C肝新藥之潛力。

Abstract

The partial purified or the pure compound isolated from single herb was tested by using cell-based HCV replicon system to evaluate anti-HCV activity. The drug toxicity was screened by using primary rat hepatocytes. The potential anti-HCV candidate has been tested using both assay systems.

技術規格

部分純化或純化合物結構、其亦抑制C病毒複製之細胞生物活性(IC50)與細胞毒性(CC50)

Technical Specification

New drug: partial purified or identified compound Bioactivity of new drug was evaluated by using HCV replicon cell system and cytotoxicitiy. IC50 indicates the drug activity to inhibit 50% HCV replication in assay system, CC50 indicates the drug toxicity to inhibit 50% of cell growth.

技術特色

1. 純化合物結構已分析出抑制C病毒複製之新用途、已完成對肝臟各種重要細胞色素P450代謝作用分析 2. 藥物口服後,血液代謝物具有抑制C病毒複製之作用 3. 專利(台灣、中國、美國、歐盟)申請中或部分已獲證

應用範圍

1.臨床治療C肝新藥 2.與治療C肝臨床藥物合併使用,增加藥物反應率與療效,降低副作用

接受技術者具備基礎建議(設備)

藥物製造

接受技術者具備基礎建議(專業)

藥物開發/臨床試驗設計/臨床試驗

技術分類 藥物治療

聯絡資訊

聯絡人:張秀鳳 小分子藥物技術組

電話:+886-3-5743919 或 Email:ShauFengChang@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5743990

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