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工業技術研究院

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技術名稱: 膠原蛋白支架技術平台

技術簡介

以膠原蛋白為支架,組合各種醫療用的蛋白藥物成為創新型藥物。

Abstract

Making multivalent protein binders by fusion of target-binding partners with a short collagen-like peptide scaffold

技術規格

膠原蛋白支架抗體,具有較傳統二價抗體藥物更優秀之抗原親合力,此外,其有別於傳統由融合瘤產生的動物性支架,可使過敏等免疫副作用顯著降低。

Technical Specification

Collagen scaffold antibodies can improve target binding strength and potentially increase therapeutic effects with reduced dosing regimen.

技術特色

膠原蛋白支架抗體具有多價特性 (Multivalency),其結構穩定並使抗體與抗原之親合力較傳統二價抗體提升數倍以上,可減少藥物使用量。

應用範圍

可應用之領域包括:(1) Targeted Therapeutics:膠原蛋白支架可蛋白藥物融合,包括抗體、內毒素、賀爾蒙、細胞激素及酵素等蛋白分子; (2) Molecular Imaging: 膠原蛋白支架可融合具螢光(GFP)、泠光(luciferase)蛋白分子或外接具放射性之蛋白分子或奈光分子與核種;(3) In vitro Diagnostics:膠原蛋白支架以其多價特性,可大幅提升抗體與抗原之親合力,進而減少抗體使用量並增加偵測靈敏度。

接受技術者具備基礎建議(設備)

哺乳類動物細胞懸浮培養生物反應器,蛋白純化設備

接受技術者具備基礎建議(專業)

細胞懸浮培養、蛋白純化

技術分類 生物工程

聯絡資訊

聯絡人:周民元 創新商機開發與前瞻技術組

電話:03-591-2144 或 Email:minyuanc@itri.org.tw

客服專線:+886-800-45-8899

傳真:03-591-0097

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