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工業技術研究院

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技術名稱: 白血病癌細胞生長抑制劑篩選技術

技術簡介

細胞毒性篩選系統,可用來篩選潛力抗白血病標靶藥物,目前此一篩選細胞包括RS4;11 (FLT3-wt)、THP-1 (FLT3-wt )、MV4-11 (Flt-3-ITD)、MOLM13 (Flt-3-ITD)及Kasumi-1 (c-KIT-wt; AML1/ETO)等細胞之分析篩選技術。

Abstract

Cell growth inhibition activities assay can be used to screen potential drugs in leukemia. The cell lines in this system contains RS4;11 (FLT3-wt)、THP-1 (FLT3-wt )、MV4-11 (Flt-3-ITD)、MOLM13 (Flt-3-ITD) and Kasumi-1 (c-KIT-wt; AML1/ETO) etc.. This evaluating platform can accelerate drug discovery/lead optimization and novel potential kinase inhibitor can also be discovered for cancer therapy.

技術規格

1.以既有藥物當控制組。 2.分析物之細胞生長抑制率(%)。 3.分析物之抑制濃度測定(IC50)。

Technical Specification

1.Existing drug as positive control. 2.Cell growth inhibition activity of determined agent. 3.Half maximal inhibitory concentration of determined agent.

技術特色

已完整建立此一分析平台,可提供分析服務;並可擴充至其他癌症細胞分析。

應用範圍

抗癌藥物篩選,藥效標靶鑑定。

接受技術者具備基礎建議(設備)

多功能分光光譜儀

接受技術者具備基礎建議(專業)

細胞學分析技術

技術分類 藥物治療

聯絡資訊

聯絡人:林美薇 標靶藥物技術中心

電話:+886-3-5912841 或 Email:Ninety@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5912516

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