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工業技術研究院

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技術名稱: 注射型抗癌藥物緩釋水膠劑型

技術簡介

利用幾丁聚醣進行疏水基修飾之生物相容性材料開發酸鹼驅動型注射型水膠新劑型,因應環境pH值由微酸變成中性時,高分子溶液可迅速固化形成水膠,此水膠新劑型裝載抗癌藥物具備長效釋控功能。

Abstract

A novel injectable pH-triggered hydrogel system composed of biocompatible hydrophobically modified chitosan was developed. The transition between solution and its resulting hydrogel occurred rapidly within a narrow pH range (pH 6.5~7.4). The hydrogel loaded with anti-cancer drug exhibited sustained drug release.

技術規格

高分子含量 7 mg/mL 藥含量 paclitaxel 10 mg/mL 體外溶離 30天50±10% 黏彈性值G’ 150±30 Pa, G” 40 ± 10 Pa, ?* 150±35 Pa.s

Technical Specification

Polymer content 7 mg/mL Drug content paclitaxel 10 mg/mL In vitro release 50±10% at day 30 Viscoelastic properties G’ 150±30 Pa, G” 40 ± 10 Pa, ?* 150±35 Pa.s

技術特色

注射型抗癌藥物緩釋水膠劑型目前已完成體外性質評估以及動物體內藥動以及藥效驗證,目前每批次製備可達100mL,並具備3個月以上的安定性。除了用於癌症治療之外,尚可包覆其他藥物用於治療慢性疾病。

應用範圍

‧癌症局部治療。 ‧精神分裂症、風濕性關節炎、荷爾蒙補充等慢性疾病。

接受技術者具備基礎建議(設備)

針劑充填設備

接受技術者具備基礎建議(專業)

藥學、化學工程、新藥新劑型開發

技術分類 藥物治療

聯絡資訊

聯絡人:呂瑞梅 標靶藥物技術中心

電話:03-5732540 或 Email:maggielu@itri.org.tw

客服專線:+886-800-45-8899

傳真:03-5732372

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