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工業技術研究院

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技術名稱: 脂質體紫杉醇新劑型

技術簡介

高疏水性藥物微脂體包覆技術具有長期安定性,同時紫杉醇(PTX)微脂粒包覆技術良好,可廣泛治療腫瘤效果

Abstract

The high drug loading technology for hydrophobic drug is unique; it is of the ability for long-term stability. Meanwhile, the liposomal paclitaxel formulation can trap drug well and apply for diverse tumor treatment.

技術規格

藥含量 paclitaxel 2 mg/mL 粒徑100.0 ± 33.3nm 藥物包覆率95% 體外溶離 72 hr < 5%

Technical Specification

Drug content paclitaxel 2 mg/mL Particle size 100.0 ± 33.3nm EE% >95% In vitro drug release 72 hr < 5%

技術特色

工研院已建立完整微脂體技術平台,包括劑型配方,藥物選擇,試量產,體外及動物評估等。本項微脂體技術可包覆高藥量疏水性藥物,藥量可達2 mg/mL且具有長期安定性,同時配方組成可由小批至50mL以上,均有良好相等性,適合於卵巢癌、肺癌等治療應用。

應用範圍

包覆抗癌藥物可應用於腫瘤;包覆醫美物質可應用於化妝品

接受技術者具備基礎建議(設備)

針劑製造相關設備

接受技術者具備基礎建議(專業)

生技製藥,新藥開發

技術分類 醫藥技術

聯絡資訊

聯絡人:呂瑞梅 標靶藥物技術中心

電話:+886-3-5732540 或 Email:maggielu@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732372

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