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工業技術研究院

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技術名稱: 建立小鼠之非酒精性脂肪肝疾病/非酒精性肝炎動物模式

技術簡介

非酒精性脂肪肝病(Non-alcoholic fatty liver disease, NAFLD)為肝臟中三酸甘油脂的異常堆積是世 界上最常見的慢性肝病,其關鍵致病因素是肥胖症、代謝 症候群,胰島素抗性和2型糖尿病等。NAFLD的肝臟組織病 變依病程進展包含了簡單的脂肪肝、非酒精性脂肪性肝炎 (Non-alcoholic steatohepatitis, NASH)到最終纖 維化之肝硬化,甚至可發展為肝癌。本技術使用雄性 BKS.Cg- Dock 7m +/+ Leprdb/JNarl (db/db)小鼠建 立非酒精性脂肪肝病動物模型以了解其複雜的致病機制理 解及合適的治療策略。

Abstract

Non-alcoholic fatty liver disease(NAFLD), the abnormal accumulation of triglycerides in the liver, is the most common chronic liver disease worldwide. NAFLD includes a spectrum of histopathological findings, ranging from simple fatty liver through non-alcoholic steatohepatitis(NASH) to fibrosis and ultimately cirrhosis, which may progress to hepatocellular carcinoma. The key pathogenetic factors of NAFLD are obesity, metabolic syndrome, insulin resistance and type 2 diabetes mellitus. We used db/db mice to apply the animal model for this disease to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic strategies.

技術規格

以小鼠餵食高熱量食物建立之非酒精性脂肪肝疾病/非酒精 性肝炎動物模式,5至15週後能成功誘導NAFLD和NASH,並 且與人類有相似的血清生化結果及肝臟的組織病理病變。

Technical Specification

Mice were fed with high fat diet to induce NAFLD / NASH. Results showed similar serum biochemistry and histopathologic patterns of human NAFLD/NASH.

技術特色

已動物模式建立,可進行分析待測樣品對小鼠之非酒精性脂肪肝疾病/非酒精性肝炎之影響

應用範圍

生技醫藥、健康食品效力驗證及機制探討

接受技術者具備基礎建議(設備)

動物飼養及試驗操作之基本環境

接受技術者具備基礎建議(專業)

實驗動物操作及觀測等專業

技術分類 醫藥技術

聯絡資訊

聯絡人:劉志鵬 標靶藥物技術中心

電話:+88635732620 或 Email:cpliu@itri.org.tw

客服專線:+886-800-45-8899

傳真:+88635732359

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