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工業技術研究院

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技術名稱: 紅斑性狼瘡疾病動物模式

技術簡介

NZBWF1小鼠可自發性產生自體免疫反應其症狀與紅斑性狼瘡 病患相似。自體免疫反應包括產生抗細胞核抗體,高尿蛋白 與因免疫複合物沉積而造成的腎絲球腎炎。由於NZBWF1產生 的自體免疫反應是由多基因共同造成,此特徵與臨床病患相 似,所以適合當作紅斑性狼瘡的疾病動物模式。

Abstract

NZBWF1 mouse development autoimmune response that is correlated to Systemic lupus erythematosus (SLE). The autoimmunity include anti-nuclear antibody, proteinuria and glomerulonephritis induced by immune complex. Due to the disease of NZBWF1 mouse is polygenic which is assemble to SLE, the mouse is appropriate to be the disease model of SLE.

技術規格

1.血清中含Anti-dsDNA Ab 2.高尿蛋白 3.腎絲球腎炎 4.正對照組為Methylprednisolone/Cyclophosphamide

Technical Specification

1.Anti-dsDNA in serum 2.High proteinuria 3.Glomerulonephritis 4.Methylprednisolone/Cyclophosphamide were the positive control

技術特色

技術穩定,正對照組實驗具再現性,可依需求進行預防性給藥或發病初始期給藥,實驗結束後可依需要進行腎臟組織染色

應用範圍

基礎研究、藥品、醫療器材

接受技術者具備基礎建議(設備)

ㄧ般生化實驗室,動物飼養環境

接受技術者具備基礎建議(專業)

動物實驗操作經驗

技術分類 醫藥技術

聯絡資訊

聯絡人:黃國魁 標靶藥物技術中心

電話:+886-3-5743955 或 Email:light@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732359

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