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工業技術研究院

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技術名稱: 難溶性藥物固體分散傳輸技術平台應用

技術簡介

高疏水性藥物非常適合以固體分散傳輸技術進行劑型開發, 可以提高藥物在水中的溶解度,同時增加藥物的安定性。工 研院已建立完整固體分散傳輸技術平台,包括劑型配方,藥 物選擇,試量產,體外及動物評估等。

Abstract

Highly hydrophobic drugs is very suitable to the solid dispersion formulation development, this technology can improve drug solubility and increase the stability in water. ITRI has established the fenofibrate solid dispersion formulation technology platform, including formulation design, drug selection, pilot production, in vitro, in vivo and animal study evaluation.

技術規格

藥含量 fenofibrate 20% 安定性 大於2星期無結晶態產生

Technical Specification

Drug content fenofibrate 20% Stability > 2 weeks no crystal formation

技術特色

工研院已建立完整固體分散傳輸技術平台,包括劑型配方,藥物選擇,試量產,體外及動物評估等。特色包括有: 1.提升難溶藥物或新化合物之溶解性 2.solid dispersion高藥含量配方技術 3.具有產品規格之安定性 4.提升口服生體利用率

應用範圍

包覆難溶性藥物可應用於口服劑型

接受技術者具備基礎建議(設備)

口服錠劑製造相關設備

接受技術者具備基礎建議(專業)

生技製藥,新藥開發

技術分類 醫藥技術

聯絡資訊

聯絡人:呂瑞梅 標靶藥物技術中心

電話:+886-3-5732540 或 Email:MaggieLu@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732372

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