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工業技術研究院

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技術名稱: 合成高專一性連結鏈接合之抗體藥物複合體

技術簡介

本技術為合成一高專一性接合之抗體藥物複合體,藥物釋放包括 cleavable 及non-cleavable。新穎性高專一性接合鏈,可與抗體接合形成高均質性的抗體藥物複合體 (site-specific antibody drug conjugate),此高專一性連結鏈可將藥物專一性地接合至抗體固定位置並控制接合數量,以改善傳統抗體藥物複合體接合產生高異質性問題 (heterogeneity,D0 - D8)。 本技術具備與國際競爭的能力,已完成一案五國專利正式送件申請。

Abstract

This patent is designed to synthesize a site-specific antibody-drug conjugates (ADCs) for cancer drugs with drug release which includes cleavable and non-cleavable linkers. The novel site-specific linker-toxin can be coupled with an antibody to form a highly homogenous antibody-drug conjugates. The site-specific linker-toxin can specifically bind to the antibody and control the binding quantity to improve high heterogeneity generated in the traditional antibody-drug conjugates (D0 - D8).

技術規格

none

Technical Specification

none

技術特色

本技術為合成一高專一性接合之抗體藥物複合體,藥物釋放包括 cleavable 及non-cleavable。新穎性高專一性接合鏈,可與抗體接合形成高均質性的抗體藥物複合體 (site-specific antibody drug conjugate),此高專一性連結鏈可將藥物專一性地接合至抗體固定位置並控制接合數量,以改善傳統抗體藥物複合體接合產生高異質性問題 (heterogeneity,D0 - D8)。 本技術具備與國際競爭的能力,已完成一案五國專利正式送件申請。

應用範圍

適用於抗體、蛋白藥物、胜?等藥物之接合,以產生其藥物複合體。

接受技術者具備基礎建議(設備)

具備抗體生產所需設備。

接受技術者具備基礎建議(專業)

具備抗體生產所需能力。

技術分類 醫藥技術

聯絡資訊

聯絡人:呂瑞梅 標靶藥物與傳輸技術組(0W000)

電話:+886-3-5732540 或 Email:stacylee@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732372

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