『您的瀏覽器不支援JavaScript功能,若網頁功能無法正常使用時,請開啟瀏覽器JavaScript狀態』

跳到主要內容區塊

工業技術研究院

:::

技術名稱: 可裝載高濃度蛋白質藥物之水膠載體釋控技術

技術簡介

1.本技術為利用一高生物相容性之水膠材料做為蛋白質藥物之長效釋控載體,此技術可裝載高濃度抗體或蛋白質藥物,藥物濃度可達200 mg/mL,含藥量為國際技術的6倍以上。此外,此特色水膠可達成4週之藥物緩釋,同時維持藥物之活性及結構完整性,具備改良給藥途徑及延長給藥頻率等新劑型開發之應用潛力。 2.本技術具備與國際競爭的能力,已完成一案五國專利正式送件申請。

Abstract

1.100% drug encapsulation efficiency 2.High antibody loading concentration (up to 200 mg/mL) 3.Sustained release over 4 weeks (in vitro and in vivo) 4.Intact stability and antigen binding affinity of antibody released from hydrogel 5.Unchanged anti-proliferation and ADCC capability of antibody released from hydrogel 6.Alterable release rate of antibody by changing composition of the formulation 7.Cmax reduction (40-70%) and Tmax extension (30-50%) for the trastuzumab antibody

技術規格

水膠組合物由低濃度(2~5 wt%)具生物相容性之polypeptide及poly(ethylene glycol)構成,具有多孔結構且能包覆高濃度蛋白質藥物(高達200 mg/mL),並應用於蛋白質藥物控制釋放。

Technical Specification

none

技術特色

1.本技術為利用一高生物相容性之水膠材料做為蛋白質藥物之長效釋控載體,此技術可裝載高濃度抗體或蛋白質藥物,藥物濃度可達200 mg/mL,含藥量為國際技術的6倍以上。此外,此特色水膠可達成4週之藥物緩釋,同時維持藥物之活性及結構完整性,具備改良給藥途徑及延長給藥頻率等新劑型開發之應用潛力。 2.本技術具備與國際競爭的能力,已完成一案五國專利正式送件申請。

應用範圍

適用於抗體、蛋白藥物、胜?等藥物,以產生其控釋劑型。

接受技術者具備基礎建議(設備)

具備抗體生產所需設備

接受技術者具備基礎建議(專業)

具備抗體生產所需能力

技術分類 醫藥技術

聯絡資訊

聯絡人:邱雅玲 標靶藥物與傳輸技術組(0W000)

電話:+886-3-5732591 或 Email:choya.ylchiu@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5732372

[{"text":"企業網","weight":13.0},{"text":"材化所","weight":11.5},{"text":"機械所","weight":10.0},{"text":"綠能所","weight":9.4},{"text":"生醫所","weight":8.0},{"text":"半導體","weight":6.2},{"text":"南分院","weight":5.0},{"text":"太陽能","weight":5.0},{"text":"課程","weight":5.0},{"text":"遠紅外線","weight":5.0},{"text":"雷射","weight":4.0},{"text":"LED","weight":4.0},{"text":"LED可見光","weight":3.0},{"text":"5G","weight":3.0},{"text":"工研人","weight":3.0},{"text":"電光所","weight":3.0},{"text":"綠能與環境研究所","weight":3.0},{"text":"機械","weight":3.0},{"text":"資通所","weight":2.0},{"text":"面板","weight":2.0},{"text":"文字轉語音","weight":2.0},{"text":"實習","weight":2.0},{"text":"無人機","weight":2.0},{"text":"生醫","weight":2.0},{"text":"3D","weight":2.0},{"text":"v2x","weight":2.0},{"text":"員工","weight":2.0},{"text":"地圖","weight":2.0},{"text":"太陽光電","weight":2.0},{"text":"材料與化工研究所","weight":1.0}]