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工業技術研究院

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技術名稱: 抗體功效驗證SOP

技術簡介

抗體功效驗證及品管。本技術可定量 MMAE (monomethyl auristatin E) ADC藥物 (antibody drug conjugate) 之濃度,適用於活體藥動樣本分析。本技術對於前臨床及臨床試驗ADC 研究均可適用,對 MMAE ADC 的藥物研發是絕對必要的

Abstract

ITRI developed a MMAE antibody for the quantitative evaluation of antibody-MMAE-conjugate in test samples, especially for in vivo pharmacokinetic serum samples. Our report showed the anti-MMAE antibody is useful for pre-clinical and clinical pharmacokinetics study of MMAE antibody drug conjugate (ADC).

技術規格

antibody-MMAE 抗體

Technical Specification

antibody-MMAE antibody

技術特色

本技術MMAE抗體為單株抗體,可辨識標靶抗體藥物上的 MMAE 小分子,作為酵素免疫分析法套組ELISA

應用範圍

1.定量人類、大鼠、小鼠、靈長類等之組織內、細胞株內、血清中之 MMAE ADC 濃度 2.人類單株抗體或是小鼠單株抗體接合MMAE ADC 皆可以本套組定量 3.生產單株抗體之技術可衍生製備其它 ADC 的 anti-drug Mab 及衍生之 ELISA kit

接受技術者具備基礎建議(設備)

具備生技醫藥研發應用業者

接受技術者具備基礎建議(專業)

具備生技醫藥研發應用業者

技術分類 醫藥技術

聯絡資訊

聯絡人:洪秋蓮 標靶藥物與傳輸技術組

電話:+886-3-5743961 或 Email:joyhung@itri.org.tw

客服專線:+886-800-45-8899

傳真:+886-3-5820369

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