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Industrial Technology Research Institute

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Lipid Nanoparticles (LNP) for the Delivery of Nucleotides in Ex-vivo Immune Cell Modification or In-vivo Applications

Technology Overview

ITRI has developed series of lipid nanoparticles (LNPs) with proprietary ionizable lipids. Results of in-vivo transfection of reporter mRNA in mice showed transfection efficiency of ITRI’s LNP similar as benchmark MC-3 LNP. In ex-vivo transfection of primary T and NK cells, ITRI’s LNP showed >80% transfection efficiency. ITRI’s LNP outperforms the current gold standard LNPs (MC3 and SM102) in transfection of primary T cells. ITRI’s ICT-LNP is well tolerated based on viability and proliferation data.

Features & Advantages

  • ITRI’s LNP showed comparable in-vivo transfection efficiency to benchmark MC3-LNP
  • ITRI’s LNP showed >80% mRNA transfection efficiency in primary T and NK cells
  • ITRI LNP use ITRI’s novel ionizable lipid. (US provisional patent submitted)

Applications & Benefits

Lipid nanoparticle might be used to encapsulate siRNA, DNA, mRNA and CRISPR mRNA for in-vivo application or ex-vivo immune T or NK cell modification.
RNA-LNP formulation
RNA-LNP formulation

Evaluation of RNA-LNP efficiency.
Evaluation of RNA-LNP efficiency.

ITRI's lipid nanoparticles (LNP) for nucleic acid delivery and reusable nucleic acid synthesis technology are expected to establish a technology platform that delivers nucleic acid-based therapeutics for a better life in the future.
ITRI's lipid nanoparticles (LNP) for nucleic acid delivery and reusable nucleic acid synthesis technology are expected to establish a technology platform that delivers nucleic acid-based therapeutics for a better life in the future.

Delivery of mRNA to primary T cells and NK cells.
Delivery of mRNA to primary T cells and NK cells.

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