Industrial Technology Research Institute

Technology Overview

Intra-tumoral injection of TLR9 agonists has shown promising results in immune checkpoint inhibitors (ICIs) refractory cancer, but it’s limited to the superficial cancers (e.g. melanoma, head and neck cancer, skin cancer, etc.).
ITRI has developed a novel spherical nucleic acid (SNA) TLR9 agonist by intravenous (iv) administration for deep site tumors such as microsatellite stable metastatic colorectal cancer (MSS mCRC). This study showed ITRI’s TLR9 SNA using iv injection could enhance the anti-tumor activity of ICIs and show immunological memory in ICIs resistant MSS mCRC model.

• Features and Advantages
  • Prevent nucleic acid degradation
  • Enhance immune cell uptake
  • Target tissue delivery
  • 80~100% complete remission in colon and breast tumor model
  • Induce tumor specific immune-memory effects
  • Treat deep-site tumors by intravenous administration
  • Low immunotoxicity risk
• Specifications
  • Tumor complete remission
  • Induce specific immune-memory effects, reduce tumor recurrence
  • Intravenous administration, no surgery required

Applications & Benefits

• Apply to immune checkpoint inhibitors refractory cancers
• Apply to deep-site tumor treatment (e.g. Colon, Breast)
• Have the potential for nucleic acid delivery and vaccine adjuvant

Other superior PD results

• 90% complete remission in CT26 model

• 100% complete remission in EMT6 model

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