ITRI's Hybrid Power Drone with High Payload and Duration is an octocopter that can hover up to 45 minutes at 30 kg payload, which is over three times the endurance of a drone powered solely by lithium battery. The drone consists of an optimized carbon fiber reinforced plastics (CFRP) fuselage and a hybrid power system including the lightweight aviation internal combustion engine (ICE) and the high power density electric generator and lithium batteries. With high payload, the drone can even carry granular fertilizers, proving its capabilities as an advanced agricultural drone for plant protection. It can perform robust delivery service and long range infrastructure inspection as well.